The study conducted by investigators at the Fred Hutchinson Cancer Research Center in Seattle, Washington, and Seattle Children's Hospital, was a randomized, open-label study of TCAD therapy (amantadine and ribavirin administered with oseltamivir) versus oseltamivir monotherapy in immunocompromised patients with Influenza A. The objective of the study was to assess the safety, tolerability, and virologic benefit of oral TCAD therapy. A total of seven patients with confirmed influenza A were enrolled. Data from the study demonstrated that up to 10 days of TCAD therapy was observed to be well tolerated, with five of six TCAD-treated subjects who completed the study achieving a clinical response by day 10. In contrast, the single patient in the oseltamivir monotherapy treatment arm did not respond to 20 days of treatment. Importantly, this patient developed an oseltamivir resistant strain by day seven that persisted to the end of treatment, resulting in the shedding of a multidrug resistant (MDR) strain of influenza.
Triple Combination Anti Flu Drug Being Trialled
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