From the category archives:

Tamiflu

Tamiflu resistant swine flu warning to cancer patients

Health experts have issued a warning to people with certain medical conditions and their carers after it emerged that a number of Scots are suffering from so-called super swine flu. They have called for patients with compromised immune systems – primarily cancer sufferers – to ensure they are vaccinated against swine flu after nine people [...]

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USA – 1% of flu isolates Tamiflu resistant

Among 2009 H1N1 isolates tested worldwide, 278 have been found to be resistant to oseltamivir – 64 of these isolates were detected in the United States. Approximately 1% of U.S. 2009 H1N1 viruses tested by CDC since September 30, 2009, have been resistant to oseltamivir. via CDC 2009 H1N1 Flu | 2009 H1N1 Flu: International [...]

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Laninamivir much more effective than Tamiflu

Laninamivir octanoate markedly reduced the median time to illness alleviation in comparison with oseltamivir in patients infected with oseltamivir-resistant influenza A (H1N1), and the difference was -60.9 hours in the 40-mg group and -66.2 hours in the 20-mg group. On the other hand, there were no significant differences in the time to alleviation of illness [...]

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Tamiflu resistant AH1N1 circulating in Vietnam and China?

In our study population, we found no evidence for the spontaneous emergence of resistance in untreated patients. This contrasts with very recent findings of resistance in a small number of Chinese and Vietnamese subjects who had not received oseltamivir prophylaxis or treatment [8,10]. These results have been interpreted as showing that spontaneous mutation can occur [...]

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Rapid resistance of flu drugs in immune comprimised patients

The overall impact of influenza virus infection in immunocompromised patients is largely unknown. Antigenic drift and genetic variations during prolonged influenza infection have been demonstrated. In this report we describe a multidrug-resistant H3N2 influenza virus isolated from an immunocompromised patient after 5 days of therapy. Methods. Multiple nasal wash samples were collected from an infected [...]

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H1N1 Tamiflu Resistant in Japan

he phylogenetic analysis of sequences from the H274Y positive samples indicates that H274Y is widespread and transmitting in Japan, especially in recent sequences. Of the seven 2010 isolates that have been sequenced for H274Y, six are positive. These latest HA sequences suggest that a high frequency of H274Y also applies to 2010 sequences from Nagasaki, [...]

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Flu Doctor suggest using newer flu drugs for worst cases

But the confirmation makes it clear doctors treating severely ill flu patients need to try to maximize the benefits of the few flu drugs available and minimize the risk of resistance developing, said Dr. Matthew Memoli, a physician and researcher at the National Institute of Allergy and Infectious Diseases and first author of the report. [...]

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Tamiflu Resistance In pH1N1 to Become the Norm?

NIID has released 15 NA sequences (at GISAID) and all 15 had H274Y. Five of the 15 were from 2010, which increases the number of 2010 NA sequences to seven. Six of the seven have H274Y. The frequency of H274Y in sequences released by NIID has steadily increased, but the sequence of 2010 isolates is [...]

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Resistance to swine flu drugs can develop faster than expected

The pandemic H1N1 influenza virus can develop resistance to the commonly used antiviral drugs much faster than expected, federal researchers said Friday. Previous research had suggested that it would take 24 days or longer for resistance to the drugs to develop in a patient, but a new study reported in the journal Clinical Infectious Diseases [...]

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China drought hits key Tamiflu ingredient

The severe drought ravaging southwest China, home to an ingredient in the anti-flu drug Tamiflu, may prompt Roche, Tamiflu’s biggest producer, to use substitute ingredients.Southwest China produces 85 percent of the world’s Star Anise, an ingredient of Tamiflu, and the region’s production may be “substantially reduced” as a result of the drought, said Li Changxin [...]

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