From the category archives:

Swine Flu Virus

H1N1 virus has mutated

The H1N1 virus has undergone a slight genetic mutation and its effect on patients has also changed. But patients are still responding to anti-viral drug Tamiflu. “Unlike last year, swine flu patients don’t have high fever these days. Severe sore throat and backache are the most prominent symptoms now,” said Dr G.T. Ambe, Brihanmumbai Municipal [...]

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H1N1 flu undergoing genetic changes in swine

“The particular reassortment we found is not itself likely to be of major human health risk, (but) it is an indication of what may be occurring on a wider scale, undetected,” said Malik Peiris, an influenza expert and co-author of a paper published in the June 18 issue of Science. “Other reassortments may occur, some [...]

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H1N1 flu undergoing genetic changes in swine

“The particular reassortment we found is not itself likely to be of major human health risk, (but) it is an indication of what may be occurring on a wider scale, undetected,” said Malik Peiris, an influenza expert and co-author of a paper published in the June 18 issue of Science. “Other reassortments may occur, some [...]

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Swine Flu Immunity Among Older People Waning?

In Scotland, following the two waves of infection that have occurred so far, it appears that older people are no longer more likely to have significant levels of antibodies than young people. The seroprevalence among young people is, presumably, primarily due to exposure during the two waves of infection. While we currently do not have [...]

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Swine Flu Lacks Killer Molecule

While the two surface proteins are important, it’s really PB1-F2 that gave the Spanish flu its punch, Palese told scientists gathered June 14 for Genetics 2010: Model Organisms to Human Biology, a meeting of the Genetics Society of America. Now, he and his colleagues have discovered that the viral protein prevents the body from making [...]

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Swine Flu – what we’re learning one year on

Given these inherent limitations in the data, however, some consistent observations have been noted. The results of the baseline seroepidemiological surveys provided reasonably consistent evidence that cross-protective immunity from previously circulating H1N1 strains increases with age, with the highest levels occurring in individuals aged >60 years. This finding may explain the low observed rates of [...]

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Flu’s secret evolution strategy unveiled

Flu’s secret formula for effectively evolving within and between host species has been unveiled. Scientists have said that the key lies with the flu’s unique replication process, which has evolved to produce enough mutations for the virus to spread and adapt to its host environment, but not so many that unwanted genomic mutations lead to [...]

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Structural Basis of Pre-existing Immunity to the 2009 H1N1 Pandemic Influenza Virus

These structures clearly illustrate the high degree of conservation in the Sa site between the 2009 H1N1 flu and the hemagglutinins of H1N1 viruses found during the first decades of the 20th century. Exposure to older viruses circulating from 1918 through the 1930's or 1940's likely elicited 2D1-like antibodies that can cross-react with the 2009 [...]

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Comparative spread of pandemic and season flu in households

Secondary attack rates (as confirmed on RT-PCR assay) among household contacts of index patients were similar for the pandemic influenza virus (8%; 95% confidence interval [CI], 3 to 14) and seasonal influenza viruses (9%; 95% CI, 5 to 15). The patterns of viral shedding and the course of illness among index patients were also similar [...]

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At least 28 swine flu variants infected Japan

At least 28 genetically different types of the H1N1 swine flu virus have entered Japan since the time of the outbreak last spring to late September, researchers at the Infectious Disease Surveillance Center said Wednesday. The first types of the “new” virus, which spread through Kobe and Osaka in the initial phase of Japan's outbreak [...]

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